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Insilico details AI discovery of fibrosis drug INS018_055 in Nature Biotechnology

See how this story connects

Source: Nature Biotechnology (doi:10.1038/s41587-024-02143-0)

Insilico Medicine researchers reported in Nature Biotechnology on 8 March 2024 how they used AI to pick TNIK as a target for idiopathic pulmonary fibrosis and to generate INS018_055, a small-molecule TNIK inhibitor. A phase I trial in 78 healthy participants (NCT05154240) and a separate phase I in China supported its safety and pharmacokinetics, and the paper says target discovery to preclinical candidate took about 18 months.

Why it matters

Drug developers had peer-reviewed detail of a candidate whose target and molecule both came from AI, with human safety data, for a lung disease with few treatments.

When
8 Mar 2024
ID
WTA-N-2024-0006
Who
Insilico Medicine

Summary by wheresthe.ai, from Nature Biotechnology. Checked against the source on 9 Oct 2026.

Read the original at Nature Biotechnology

Source copy: download the page as saved on 18 Oct 2026 (PDF). Documents the source offers: document 1 (PDF), document 2 (PDF). Also held by the Internet Archive.

Next stop on this Storyline: Led toInsilico doses first patients in Phase III trial of AI-discovered drug rentosertib

Cite this story

WTA-N-2024-0006: “Insilico details AI discovery of fibrosis drug INS018_055 in Nature Biotechnology.” wheresthe.ai, 8 Mar 2024. https://wheresthe.ai/d/cn-insilico-tnik-inhibitor-paper-2024-03/ (source: Nature Biotechnology (doi:10.1038/s41587-024-02143-0)).

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