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Google DeepMind releases AlphaGenome 2 to predict DNA variant effects in human cell types

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Source: Google DeepMind

Google DeepMind announced AlphaGenome 2, a conditional model that predicts how a DNA sequence and its variants act in one chosen cell type, tissue or state at a time. It was trained on more than 100 million individual cell profiles across 68 tissues. On the TenK10K dataset of 28 primary immune cell types, it identified 30% of causal variants against 16% for the original AlphaGenome fine-tuned on single-cell data, and 43% of directional gene effects against 23%.

Why it matters

Non-commercial researchers can use AlphaGenome 2 through its API today, commercial research is in private preview, and it is not validated for clinical or diagnostic use.

When
11 Nov 2026
ID
WTA-N-2026-0851
Who
Google DeepMind

Summary written with AI by wheresthe.ai, from Google DeepMind. Checked against the source on 11 Nov 2026.

Read the original at Google DeepMind

Source copy: saved on 11 Nov 2026 to check this story and not republished, because the text belongs to its publisher. Also held by the Internet Archive.

Cite this story

WTA-N-2026-0851: “Google DeepMind releases AlphaGenome 2 to predict DNA variant effects in human cell types.” wheresthe.ai, 11 Nov 2026. https://wheresthe.ai/d/intl-deepmind-alphagenome-2-cell-type-dna-model-2026-11/ (source: Google DeepMind).

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